[alBYOUterohl Pregnancy Category C

Alti-Salbutamol Sulfate M, Asmavent M, Gen-Salbutamol Sterinebs P.F. M, Novo-Salmol Inhaler M, PMS-Salbuta-mol Respirator Solution M, Proventil, Proventil HFA—3M, Proventil Repet-abs, Rho-Salbutamol M, Sabulin M, Salbutamol Nebuamp M, Ventodisk Disk/Diskhaler M, Ventolin, Ventolin Rotacaps, Volmax [Rx] Classification: Direct-acting adrener-gic (sympathomimetic) agent

See also Sympathomimetic Drugs. Action/Kinetics: Albuterol stimulates beta-2 receptors of the bronchi, leading to bronchodilation. Has minimal beta-1 activity. Albuterol sulfate is now available as an inhaler that contains no chlorofluorocarbons (Proventil HFA-3M). Onset, PO: 15-30 min; inhalation, 5-15 min. Peak effect, PO: 2-3 hr; inhalation, 60-90 min (after 2 inhalations). Duration, PO: 8 hr (up to 12 hr for extended-release); inhalation, 3-6 hr. Metabolites and unchanged drug excreted in urine and feces. Tablets not to be used in children less than 12 years of age.

Uses: Bronchial asthma; broncho-spasm due to bronchitis or emphysema; bronchitis; reversible obstructive pulmonary disease in those 4 years of age and older; exercise-induced bronchospasm. Prophylaxis of bronchial asthma or bronchospasms. Pa-renteral for treatment of status asth-maticus. Non-FDA Approved Uses: Nebulized albuterol may be useful as an adjunct to treat serious acute hy-perkalemia in hemodialysis clients. Contraindications: Aerosol for prevention of exercise-induced bronchospasm is not recommended for children less than 12 years of age. Use during lactation. Special Concerns: Dosage has not been established for the syrup in children less than 2 years of age, for tablets in children less than 6 years of age, and for extended-release tablets in children less than 12 years of age. Albuterol may delay preterm labor.

Additional Side Effects: Oral: Dry mouth, teeth discoloration, oropharyngeal edema. GI: Diarrhea, increased appetite, epigastric pain. CNS: CNS stimulation, malaise, emotional lability, fatigue, lightheadedness, nightmares, disturbed sleep, aggressive behavior, irritability. Respiratory: Bronchitis, epistaxis, hoarseness (especially in children), nasal congestion, increase in sputum. Hypersensitivity (may be immediate): Urticaria, angioedema, rash, bronchospasm. Miscellaneous: Muscle cramps, pallor, conjunctivitis, dilated pupils, difficulty in urination, muscle spasm, voice changes.

How Supplied: Metered dose inhaler: 0.09 mg/inh; Capsule: 200 mcg; Solution: 0.083%, 0.5%; Syrup: 2 mg/5 mL; Tablet: 2 mg, 4 mg; Tablet, Extended Release: 4 mg, 8 mg

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