[thighohRIDahzeen Pregnancy Category C

Apo-Thioridazine M, Mellaril, Mellaril-S, Novo-Ridazine M, PMS-Thioridazine M, Thioridazine HCl Intensol Oral [Rx] Classification: Antipsychotic, piperi-dine-type phenothiazine

See also Antipsychotic Agents, Phen-othiazines.

Action/Kinetics: High incidence of hypotension; moderate incidence of sedative and anticholinergic effects and weak antiemetic and extrapyramidal effects. Can often be used in clients intolerant of other phenothia-zines. Peak plasma levels (after PO administration): 1-4 hr. May impair its own absorption at higher doses due to the strong anticholinergic effects. tV2: 10 hr. Metabolized in the liver to both active and inactive metabolites. Uses: Acute and chronic schizophrenia; moderate to marked depression with anxiety; sleep disturbances. In children: Treatment of hyperactiv-ity in clients and those with retarded and behavior problems. Geriatric clients with organic brain syndrome. Alcohol withdrawal. Intractable pain.

Special Concerns: Safe use during pregnancy has not been established. Dosage has not been established in children less than 2 years of age. Geriatric, emaciated, or debilitated clients usually require a lower initial dose.

Additional Side Effects: More likely to cause pigmentary retinopathy than other phenothiazines. How Supplied: Oral concentrate: 30 mg/mL, 100 mg/mL; Tablet: 10 mg, 15 mg, 25 mg, 50 mg, 100 mg, 150 mg, 200 mg


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