Acarbose

[ah-KAR-bohs] Pregnancy Category: B

Prandase M, Precose [Rx] Classification: Antidiabetic agent

Action/Kinetics: Acarbose delays the intestinal absorption of glucose resulting in a smaller increase in blood glucose following meals. Approximately 65% of an oral dose of acarbose remains in the GI tract, which is the site of action. Metabolized in the GI tract by both intestinal bacteria and intestinal enzymes. The acar-bose and metabolites that are absorbed are excreted in the urine. Uses: Used alone, with diet control, to decrease blood glucose in type 2 diabetes mellitus. Also, used with a sulfonylurea when diet plus either acarbose or a sulfonylurea alone do not control blood glucose adequately.

Contraindications: Diabetic ketoa-cidosis, cirrhosis, inflammatory bowel disease, colonic ulceration, partial intestinal obstruction or predisposition to intestinal obstruction, chronic intestinal diseases associated with marked disorders of digestion or absorption, conditions that may deteriorate as a result of increased gas formation in the intestine. In significant renal dysfunction. Severe, persistent bradycardia. Lactation. Special Concerns: Safety and efficacy have not been determined in children. Acarbose does not cause hypo-glycemia; however, sulfonylureas and insulin can lower blood glucose sufficiently to cause symptoms or even life-threatening hypoglycemia. Side Effects: GI: Abdominal pain, diarrhea, flatulence. GI side effects may be severe and be confused with paralytic ileus. Drug Interactions Charcoal / l Effect of acarbose Digestive enzymes / l Effect of acar-bose

Digoxin / l Serum digoxin levels Insulin / T Hypoglycemia which may cause severe hypoglycemia Sulfonylureas / T Hypoglycemia which may cause severe hypoglyce-mia

How Supplied: Tablet: 50 mg, 100 mg

Dosage-

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