Acetylcysteine

[ah-see-till-SIS-tay-een] Pregnancy Category: B Mucomyst, Mucosil, Parvolex (Rx) Classification: Mucolytic

Action/Kinetics: Acetylcysteine reduces the viscosity of purulent and nonpurulent pulmonary secretions and facilitates their removal by splitting disulfide bonds. Action increases with increasing pH (peak: pH 7-9). Onset, inhalation: Within 1 min; by direct instillation: immediate. Time to peak effect: 5-10 min. Uses: Adjunct in the treatment of acute and chronic bronchitis, emphysema, tuberculosis, pneumonia, bronchiectasis, atelectasis. Routine care of clients with tracheostomy, pulmonary complications after thoracic or CV surgery, or in posttraumat-ic chest conditions. Pulmonary complications of cystic fibrosis. Diagnostic bronchial asthma. Antidote in acetaminophen poisoning to reduce hepatotoxicity. Non-FDA Approved Uses: As an ophthalmic solution for dry eye.

Contraindications: Sensitivity to drug.

Special Concerns: Use with caution during lactation, in the elderly, and in clients with asthma. Side Effects: Respiratory: Increased incidence of bronchospasm in clients with asthma. Increased amount of liquefied bronchial secretions, which must be removed by suction if cough is inadequate. Bronchial and tracheal irritation, tightness in chest, bronchoconstriction. Oral: Stomatitis. GI: N&V. Other: Rashes, fever, drowsiness, rhinorrhea. Drug Interactions: Acetylcysteine is incompatible with antibiotics and should be administered separately.

D Obstructive respiratory diseases are contraindicated with nitrous oxide. How Supplied: Solution: 10%, 20%

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