5-15 mcg/mL after 1 hr. tVi: PO, 36-54 min. Well absorbed from GI tract. From 60% to 85% excreted in urine within 8 hr.
Uses: Otitis media due to Streptococcus pneumoniae, Hemophilus influenzae, Streptococcus pyogenes, and staphylococci. Upper respiratory tract infections (including pharyngitis and tonsillitis) caused by S. pyo-genes. Lower respiratory tract infections (including pneumonia) due to S. pneumoniae, H. influenzae, and S. pyogenes. Skin and skin structure infections due to Staphylococcus aure-us and S. pyogenes. UTIs (including pyelonephritis and cystitis) caused by Escherichia coli, Proteus mirabilis, Klebsiella, and coagulase-negative staphylococci. Extended-release tablets: Acute bacterial exacerbations of chronic bronchitis due to non-ß-lac-tamase-producing strains of H. in-fluenzae, Moraxella catarrhalis (including ß-lactamase-producing strains), or S. pneumoniae. Secondary bacterial infections of acute bronchitis due to H. influenzae (non-ß-lactamase-producing strains only), M. catarrhalis (including ß-lactamase-producing strains), or S. pneumoniae. Pharyngitis or tonsillitis due to S. pyogenes. Uncomplicated skin and skin structure infections due to S. aureus (methicillin-susceptible). Non-FDA Approved Uses: Acute uncomplicated UTIs in select populations using a single dose of 2 g.
Contraindications: Hypersensitiv-ity to cephalosporins or related penicillin antibiotics.
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