Additional Contraindications

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Pregnancy and lactation. PO indo-methacin in children under 14 years of age. GI lesions or history of recurrent GI lesions. IVuse: GI or intracra-nial bleeding, thrombocytopenia, renal disease, defects of coagulation, necrotizing enterocolitis. Suppositories: Recent rectal bleeding, history of proctitis.

Special Concerns: Use in children should be restricted to those unresponsive to or intolerant of other anti-inflammatory agents; efficacy has not been determined in children less than 14 years of age. Geriatric clients are at greater risk of developing CNS side effects, especially confusion. To be used with caution in clients with history of epilepsy, psychiatric illness, or parkinsonism and in the elderly. Indomethacin should be used with extreme caution in the presence of existing, controlled infections.

Additional Side Effects: Reactivation of latent infections may mask signs of infection. More marked CNS manifestations than for other drugs of this group. Aggravation of depression or other psychiatric problems, epilepsy, and parkinsonism.

Additional Drug Interactions Captopril / Indomethacin i effect of captopril, probably due to inhibition of prostaglandin synthesis Diflunisal / T Plasma levels of indo-methacin; also, possible fatal GI hemorrhage

Diuretics (loop, potassium-sparing, thiazide) / Indomethacin may reduce the antihypertensive and nat-riuretic action of diuretics Lisinopril / Possible i effect of lisin-opril

Prazosin / Indomethacin i antihy-pertensive effects of prazosin How Supplied: Indomethacin: Capsule: 25 mg, 50 mg; Capsule, extended release: 75 mg; Suppository: 50 mg; Suspension: 25 mg/5 mL Indomethacin sodium trihydrate: Powder for injection: 1 mg


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