Adults with normal renal function

Infections. 1 mg/kg q 8 hr, up to 5 mg/kg/day in life-threatening infections; children: 2-2.5 mg/kg q 8 hr; infants and neonates: 2.5 mg/kg q 8 hr; premature infants or neonates less than 1 week of age: 2.5 mg/kg q 12 hr. Therapy may be required for 7-10 days.

Prevention of bacterial endocarditis, dental or respiratory tract procedures.

Adults: 1.5 mg/kg gentamicin (not to exceed 80 mg) plus 1 g ampi-cillin, each IM or IV, 30-60 min before the procedure; one additional dose of each can be given 8 hr later (alternative: penicillin V, 1 g PO, 6 hr after initial dose).

Prophylaxis of bacterial endocarditis in GI or GU tract procedures or surgery.

Adults: 1.5 mg/kg gentamicin (not to exceed 80 mg) plus 2 g ampi-cillin, each IM or IV, 30-60 min before procedure; dose should be repeated 8 hr later. Children: 2 mg/kg gen-tamicin plus penicillin G, 30,000 units/kg, or ampicillin, 50 mg/kg in same dosage interval as for adults. Pediatric dosage should not exceed single or 24-hr adult doses.

NOTE: In clients allergic to penicillin, vancomycin, 1 g IV given slowly over 1 hr, may be substituted; the dose of vancomycin should be repeated 8-12 hr later. Adults with impaired renal function: To calculate interval (hr) between doses, multiply serum creatinine level (mg/100 mL) by 8.

Initially: 1-2 mg/kg infused over 30-60 min; then, maintenance doses may be administered.

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