Amitriptyline hydrochloride

[ah-me-TRIP-tih-leen] Pregnancy Category: C

Apo-Amitriptyline M, Elavil, Levate M [Rx], Novo-Tryptin M Classification: Antidepressant, tricy-clic

See also Antidepressants, Tricyclic.

Action/Kinetics: Amitriptyline is metabolized to an active metabolite, nortriptyline. Has significant anti-cholinergic and sedative effects with moderate orthostatic hypotension. Very high ability to block serotonin uptake and moderate activity with respect to norepinephrine uptake. Effective plasma levels of ami-triptyline and nortriptyline: Approximately 110-250 ng/mL. Time to reach steady state: 4-10 days. tV2: 31-46 hr. Up to 1 month may be required for beneficial effects to be manifested. Amitriptyline is also found in Limbritrol and Triavil. Uses: Relief of symptoms of depression, including depression accompanied by anxiety and insomnia. Chronic pain due to cancer or other pain syndromes. Prophylaxis of cluster and migraine headaches. Non-FDA Approved Uses: Pathologic laughing and crying secondary to forebrain disease, bulimia nervosa, antiulcer agent, enuresis. Contraindications: Use in children less than 12 years of age. How Supplied: Injection: 10 mg/mL; Tablet: 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg

Dosage-

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