Amoxicillin amoxycillin

[ah-mox-ih-SILL-in] Amox M, Amoxil, Amoxil Pediatric Drops, Apo-Amoxi M, Biomox, Nova-moxin M, Nu-Amoxi M, Polymox, Poly-mox Drops, Pro-Amox M, Trimox 125, 250, and 500, Wymox [Rx]

NOTE: Canadian products are all amoxicillin trihydrate. Classification: Antibiotic, penicillin

See also Anti-Infectives and Penicillins.

Action/Kinetics: Semisynthetic broad-spectrum penicillin closely related to ampicillin. Destroyed by penicillinase, acid stable, and better absorbed than ampicillin. From 50% to 80% of a PO dose is absorbed from the GI tract. Peak serum levels: PO: 4-11 mcg/mL after 1-2 hr. tl2: 60 min. Mostly excreted unchanged in urine.

Uses: Gram-positive streptococcal infections including Streptococcus faecalis, S. pneumoniae, and non-penicillinase-producing staphylococ-ci. Gram-negative infections due to Hemophilus influenzae, Proteus mirabilis, Escherichia coli, and Neisseria gonorrhoeae.

Contraindications: Hypersensitiv-ity to penicillins.

Special Concerns: Safe use during pregnancy has not been established. Hypersensitivity to cephalosporins. Side Effects: See also Anti-Infectives and Penicillins.

Drug Interactions: See also Anti-Infectives and Penicillins. How Supplied: Capsule: 250 mg, 500 mg; Chew tablet: 125 mg, 250 mg; Powder for reconstitution: 50 mg/mL, 125 mg/5 mL, 250 mg/5 mL

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