Antiemetic Adults and children initial

mg/m2 1-3 hr before chemotherapy; then, 5 mg/m2 q 2-4 hr for a total of four to six doses/day. If ineffective, this dose may be increased by 2.5 mg/m2 to a maximum of 15 mg/m2/dose. However, the incidence of serious psychoactive side effects increases dramatically at these higher dose levels.

Appetite stimulation. Initial: 2.5 mg b.i.d. before lunch and dinner. If unable to tolerate 5 mg/day, reduce the dose to 2.5 mg/day as a single evening or bedtime dose. If side effects are absent or minimal and an increased effect is desired, the dose may be increased to 2.5 mg before lunch and 5 mg before dinner (or 5 mg at lunch and 5 mg after dinner). The dose may be increased to 20 mg/day in divided doses. The incidence of side effects increases at higher doses.

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