Astemizole

(ah-STEM-ih-zohl] Pregnancy Category: C Hismanil [Rx]

Classification: Antihistamine, miscellaneous

See also Antihistamines. Action/Kinetics: Low to no sedative, antiemetic, or anticholinergic effects. Absorption decreased up to 60% when taken with food. Metabolized in the liver to both active and inactive metabolites and excreted through the feces. tV2: About 1.6

112 ASTEMIZOLE

Ddays. Onset: 2-3 days. Duration: Up to several weeks. Over 95% is bound to plasma protein. Mainly excreted through the feces. Uses: Allergic rhinitis, urticaria. Contraindications: Impaired hepatic function.

Special Concerns: Safety and efficacy have not been established in children less than 12 years of age. Dose should not exceed 10 mg/day.

Additional Side Effects: Serious CV side effects, including death, cardiac arrest, QT interval prolongation, torsades depointes and other ventricular arrhythmias have been observed in clients exceeding the recommended dose of astemizole. Syncope may precede severe arrhythmias. Overdose may be observed with doses as low as 20-30 mg/day. Drug Interactions: Concomitant use of astemizole with erythromycin, itraconazole, or ketoconazole may cause serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias (including QT interval prolongation).

How Supplied: Tablet: 10 mg

Dosage-

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