(ah-TEN-oh-lohl] Pregnancy Category: C
Apo-Atenol M, Gen-Atenolol M, Med-Atenolol M, Novo-Atenol M, Nu-Atenol M, Taro-Atenolol M, Tenolin M, Tenormin [Rx]
Classification: Beta-adrenergic blocking agent
Action/Kinetics: Predominantly beta-1 blocking activity. Has no membrane stabilizing activity or intrinsic sympathomimetic activity. Low lipid solubility. Peak blood levels: 2-4 hr. tVi: 6-9 hr. 50% eliminated unchanged in the feces. Uses: Hypertension (either alone or with other antihypertensives such as thiazide diuretics). Angina pectoris due to hypertension, coronary atherosclerosis, and AMI. Non-FDA Approved Uses: Prophylaxis of migraine, alcohol withdrawal syndrome, situational anxiety, ventricular arrhythmias, prophylacti-cally to reduce incidence of supraven-tricular arrhythmias in coronary artery bypass surgery. Contraindications: Hypersensitiv-ity to atenolol, cardiogenic shock, 2nd or 3rd degree heart block, sinus bradycardia, congestive heart failure, cardiac failure. Special Concerns: Aortic or mitral valve disease, asthma, COPD, diabetes mellitus, major surgery, renal disease, thyroid disease, well-compensated heart failure. Side Effects: Oral: Dry mouth. CV: Bradycardia, CHF, cold extremities, postural hypotension, profound hypotension, 2nd or 3rd degree heart block. CNS: Catatonia, depression, dizzi-
ness, drowsiness, fatigue, hallucinations, insomnia, lethargy, mental changes, memory loss, strange dreams. GI: Diarrhea, ischemic colitis, nausea, mesenteric arterial thrombosis, vomiting. Hematologic: Agranulocytosis, thrombocytopenia. Allergic: Fever, sore throat, respiratory distress, rash, pharyngitis, laryngos-pasm, anaphylaxis. Skin: Pruritus, rash, increased skin pigmentation, sweating, dry skin, alopecia, skin irritation, psoriasis. Ophthalmic: Dry, burning eyes. GU: Dysuria, impotence, nocturia. Other: Hypoglycemia or hyperglycemia. Respiratory: Bronchospasm, dyspnea, wheezing. Drug Interactions: See also Drug Interactions for Beta-Adrenergic Blocking Agents and Antihypertensive Agents.
How Supplied: Injection: 0.5 mg/mL; Tablet: 25 mg, 50 mg, 100 mg
Hypertension. Initial: 50 mg/day, either alone or with diuretics; if response is inadequate, 100 mg/day. Doses higher than 100 mg/day will not produce further beneficial effects. Maximum effects usually seen within 1—2 weeks.
Initial: 50 mg/day; if maximum response is not seen in 1 week, increase dose to 100 mg/day (some clients require 200 mg/day).
Alcohol withdrawal syndrome. 50-100 mg/day.
Prophylaxis of migraine. 50-100 mg/day.
Ventricular arrhythmias. 50-100 mg/day.
Prior to coronary artery bypass surgery.
50 mg/day started 72 hr prior to surgery.
Adjust dosage in cases of renal failure to 50 mg/day if creatinine clearance is 15-35 mL/min/1.73 m2 and to 50 mg every other day if crea-
tinine clearance is less than 15 mL/min/1.73 m2. • IV
Acute myocardial infarction. Initial: 5 mg over 5 min followed by a second 5-mg dose 10 min later. Begin treatment as soon as possible after client arrives at the hospital. In clients who tolerate the full 10-mg dose, give a 50-mg tablet 10 min after the last IV dose followed by another 50-mg dose 12 hr later. Then, 100 mg/day or 50 mg b.i.d. for 6-9 days (or until discharge from the hospital).
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Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...