Atorvastatin calcium

[ah-TORE-vah-stah-tin] Pregnancy Category: X Lipitor [Rx]

Classification: Antihyperlipidemic, HMG-CoA reductase inhibitor

See also Antihyperlipidemic Agents—HMG-CoA Reductase Inhibitors.

Action/Kinetics: Atorvastatin undergoes first-pass metabolism. t1/2: 14 hr. The drug is over 98% bound to plasma proteins. Plasma levels are not affected by renal disease

Dbut they are markedly increased with chronic alcoholic liver disease. Uses: Adjunct to diet to reduce elevated total and LDL cholesterol levels in primary hypercholesterolemia (Types IIa and IIb) when the response to diet and other nondrug measures alone have been inadequate.

Contraindications: Active liver disease or unexplained persistently high liver function tests. Pregnancy, lactation.

Special Concerns: Safety and efficacy have not been determined in children less than 18 years of age. Side Effects: See also Antihyperlipi-demic Agents—HMG-CoA Reductase Inhibitors. GI: Altered liver function tests (usually within the first 3 months of therapy). Musculoskeletal: Myalgia. Miscellaneous: Infection, hypersensitivity reactions, photosen-sitivity.

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