Bethanechol chloride

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[beh-THAN-eh-kohl] Pregnancy Category: C

Duvoid, Myotonachol, PMS-Bethane-chol Chloride M, Urecholine [Rx] Classification: Cholinergic (parasym-pathomimetic), direct-acting

Action/Kinetics: Directly stimulates cholinergic receptors, primarily muscarinic type. This results in stimulation of gastric motility, increases gastric tone, and stimulates the de-trusor muscle of the urinary bladder. Produces a slight transient fall of DBP, accompanied by minor reflex tachycardia. The drug is resistant to hydrolysis by acetylcholinesterase, which increases its duration of action. PO: Onset, 30-90 min; maximum: 60-90 min; duration: up to 6 hr. SC: Onset, 5-15 min; maximum: 15-30 min; duration: 2 hr. Uses: Postpartum or postoperative urinary retention, neurogenic atony of the bladder with urinary retention. Non-FDA Approved Uses: Reflux esophagitis in adults and gastroe-sophageal reflux in infants and children.

Contraindications: Hypotension, hypertension, CAD, coronary occlusion, AV conduction defects, vasomotor instability, pronounced brady-cardia, peptic ulcer, asthma (latent or active), hyperthyroidism, parkin-sonism, epilepsy, obstruction of the bladder, if the strength or integrity of the GI or bladder wall is questionable, peritonitis, GI spastic disease, inflammatory lesions of the GI tract, marked vagotonia. Not to be used IM or IV.

Special Concerns: Use with caution during lactation. Safety and effectiveness have not been determined in children.

Side Effects: Serious side effects are uncommon with PO dosage but more common following SC use. Oral: Salivation. GI: Nausea, diarrhea, GI upset, involuntary defecation, cramps, colic, belching, rumbling/gurgling of stomach. CV: Hypotension with reflex tachycardia, vasomotor response. CNS: Headache, malaise. Other: Flushing, sensation of heat about the face, sweating, urinary urgency, attacks of asthma, bronchial constriction, miosis, lacrimation.

Drug Interactions Cholinergic inhibitors / Additive cholinergic effects

How Supplied: Injection: 5 mg/mL; Tablet: 5 mg, 10 mg, 25 mg, 50 mg


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