Bitolterol mesylate

(bye-TOHL-ter-ohl] Pregnancy Category: C Tornalate Aerosol (Rx) Classification: Bronchodilator

See also Sympathomimetic Drugs. Action/Kinetics: Bitolterol is a pro-drug in that it is converted by esterases in the body to the active colterol. Colterol combines with beta-2-adrenergic receptors, producing dilation of bronchioles. Minimal beta-1-adrenergic activity. Onset following inhalation: 3-4 min. Time to peak effect: 30-60 min. Duration: 5-8 hr.

Uses: Prophylaxis and treatment of bronchial asthma and bron-chospasms. Treatment of bronchitis, emphysema, bronchiectasis, and COPD. May be used with theo-phylline and/or steroids. Special Concerns: Safety has not been established for use during lactation and in children less than 12 years of age. Use with caution in is-chemic heart disease, hypertension, hyperthyroidism, diabetes mellitus, cardiac arrhythmias, seizure disorders, or in those who respond unusually to beta-adrenergic agonists. There may be decreased effectiveness in steroid-dependent asthmatic clients. Hypersensitivity reactions may occur.

Additional Side Effects: CNS: Hy-peractivity, hyperkinesia, lighthead-edness. CV: Premature ventricular contractions. Other: Throat irritation. Drug Interactions: Additive effects with other beta-adrenergic bron-chodilators.

How Supplied: Metered dose inhaler: 0.37 mg/inh; Solution: 0.2%


• Metered Dose Inhaler


Adults and children over 12 years: 2 inhalations at an interval of 1-3 min q 8 hr (if necessary, a third inhalation may be taken). The dose should not exceed 3 inhalations q 6 hr or 2 inhalations q 4 hr.

Prophylaxis of bronchospasm.

Adults and children over 12 years: 2 inhalations q 8 hr.

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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