Anticonvulsant. Adults: Dose range of 900-1,800 mg/day in three divided doses. Titration to an effective dose can begin on day 1 with 300 mg followed by 300 mg b.i.d. on day 2 and 300 mg t.i.d. on day 3. If necessary, the dose may be increased to 300-400 mg t.i.d., up to 1,800 mg/day. In clients with a creatinine clearance of 30-60 mL/min, the dose is 300 mg b.i.d.; if the creatinine clearance is 15-30 mL/min, the dose is 300 mg/day; if the creatinine clearance is less than 15 mL/min, the dose is 300 mg every other day.
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