Capsules

Solid tumors, intermittent therapy or when used together with irradiation.

Dose individualized. Usual: 80

mg/kg as a single dose every third day. Intermittent dosage offers advantage of reduced toxicity. If effective, maintain client on drug indefinitely unless toxic effects preclude such a regimen.

Solid tumors, continuous therapy. 20—30 mg/kg/day as a single dose.

Resistant chronic myelocytic leukemia.

20—30 mg/kg/day in a single dose or two divided daily doses.

Concomitant therapy with irradiation for carinoma of the head and neck.

80 mg/kg as a single dose every third day.

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