Capsules Soft Gelatin Effervescent Tablets and Granules Syrup Tablets

Duodenal ulcer, short-term. Adults: 150 mg b.i.d. or 300 mg at bedtime to heal ulcer, although 100 mg b.i.d. will inhibit acid secretion and may be as effective as the higher dose. Maintenance: 150 mg at bedtime.

Pathologic hypersecretory conditions.

Adults: 150 mg b.i.d. (up to 6 g/day has been used in severe cases).

Benign gastric ulcer. Adults: 150 mg b.i.d. for active ulcer. Maintenance: 150 mg at bedtime Gastroesophageal reflux disease. Adults: 150 mg b.i.d.

Erosive esophagitis. Adults: 150 mg q.i.d.

Maintenenace of healing of erosive esophagitis. Adults: 150 mg b.i.d. • IM, IV

Treatment and maintenance for duodenal ulcer, hypersecretory conditions, gastroesophageal reflux. Adults, IM: 50 mg q 6-8 hr. Intermittent IV injection or infusion: 50 mg q 6-8 hr, not to exceed 400 mg/day. Continuous IV infusion: 6.25 mg/hr.

Zollinger-Ellison clients. Continuous IV infusion: Dilute ra-nitidine in 5% dextrose injection to a concentration no greater than 2.5 mg/mL with an initial infusion rate of 1 mg/kg/hr. If after 4 hr the client shows a gastric acid output of greater than 10 mEq/hr or if symptoms appear, the dose should be increased by 0.5-mg/kg/hr increments and the acid output measured. Doses up to 2.5 mg/kg/hr may be necessary.

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