Hypertension. Initial: 30 mg b.i.d. (range: 30-60 mg b.i.d.).
NOTE: In renal impairment, the initial dose should be 20 mg t.i.d. In hepatic impairment, the initial dose should be 20 mg b.i.d.
• IV Hypertension.
Individualize dose. Initial: 5 mg/hr; the infusion rate may be increased to a maximum of 15 mg/hr (by 2.5-mg/hr increments q 15 min). For a more rapid reduction in BP, initiate at 5 mg/hr but increase the rate q 5 min in 2.5-mg/hr increments until a maximum of 15 mg/hr is reached. Maintenance: 3 mg/hr. The IV infusion rate to produce an average plasma level similar to a particular PO dose is as follows: 20 mg q 8 hr is equivalent to 0.5 mg/hr; 30 mg q 8 hr is equivalent to 1.2 mg/hr;
and 40 mg q 8 hr is equivalent to 2.2 mg/hr.
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Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...