Mild to moderate infections. Adults, usual: 500 mg b.i.d. or 250 mg q.i.d.
Severe infections. Adult: 500 mg q.i.d. Children over 8 years: 25-50 mg/kg/day in four equal doses.
Brucellosis. 500 mg q.i.d. for 3 weeks with 1 g streptomycin IM b.i.d. for first week and once daily the second week. Syphilis.
Total of 30-40 g over 10-15 days.
Gonorrhea. Initially, 1.5 g; then, 500 mg q 6 hr until 9 g has been given.
Gonorrhea sensitive to penicillin. Initially, 1.5 g; then, 500 mg q 6 hr for 4 days (total: 9 g).
GU or rectal Chlamydia trachomatis infections.
Severe acne. Initially, 1 g/day; then, 125-500 mg/day (long-term). NOTE: The CDC have established treatment schedules for STDs. Initially, 1 g/day; then, 125-500 mg/day (long-term).
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