Capsules Tablets

Amebiasis: Acute amebic dysentery or amebic liver abscess. Adult: 500-750 mg t.i.d. for 5-10 days; pediatric: 35-50 mg/kg/day in three divided doses for 10 days.

Trichomoniasis, female. 250 mg t.i.d. for 7 days, 2 g given on 1 day in single or divided doses, or 375 mg b.i.d. for 7 days. Pediatric: 5 mg/kg t.i.d. for 7 days. An interval of 4-6 weeks should elapse between courses of therapy. NOTE: Do not treat pregnant women during the first trimester. Male: Individualize dosage; usual, 250 mg t.i.d. for 7 days.

Giardiasis. 250 mg t.i.d. for 7 days.

• Tablets, Extended-Release Bacterial vaginosis.

One 750-mg tablet per day for 7 days.

Anaerobic bacterial infections. Adults, initially: 15 mg/kg infused over 1 hr; then, after 6 hr, 7.5 mg/kg q 6 hr for 7-10 days (daily dose should not exceed 4 g). Treatment may be necessary for 2-3 weeks, although PO therapy should be initiated as soon as possible.

Prophylaxis of anaerobic infection during surgery. Adults: 15 mg/kg given over a 30- to 60-min period, with completion 1 hr prior to surgery and 7.5 mg/kg infused over 30-60 min 6 and 12 hr after the initial dose.

After washing, apply a thin film and rub in well in the morning and evening for 9 weeks.

Bacterial vaginosis. One applicatorful (5 g) in the morning and evening for 5 days. Metro-Gel Vaginal allows for once-daily dosing at bedtime.

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