Hypertension. Initial: 400 mg/day (although 200 mg b.i.d. may be needed for optimum control; then, 400-800 mg/day (range: 200-1,200 mg/day).

Premature ventricular contractions.

Iiiilial: 200 mg b.i.d.; then, increase dose gradually to reach 600-1,200 mg/day.

Dosage should not exceed 800 mg/day in geriatric clients. In those with impaired kidney or liver function, decrease dose by 50% when creatinine clearance is 50 mL/min/1.73 m2 and by 75% when it is less than 25 mL/min/1.73 m2.

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