Cardura Cardura1 2 3 M Rx Classification Antihypertensive

Action/Kinetics: Blocks the alpha-1 (postjunctional) adrenergic receptors resulting in a decrease in systemic vascular resistance and a corresponding decrease in BP. Peak plasma levels: 2-3 hr. Peak effect: 2-6 hr. Significantly bound (98%) to plasma proteins. Metabolized in the liver to active and inactive metabolites, which are excreted through the feces and urine. tVi: 22 hr. Uses: Alone or in combination with diuretics, calcium channel blockers, or

■ beta blockers to treat hypertension.

' Treatment of BPH.

Contraindications: Clients allergic to prazosin or terazosin. Special Concerns: Use with caution during lactation, in impaired hepatic function, or in those taking drugs known to influence hepatic metabolism. Safety and effectiveness have not been demonstrated in children. Due to the possibility of severe hypotension, do not use the 2-, 4-, and 8-mg tablets for initial therapy. Side Effects: Oral: Dry mouth; CV: Dizziness (most frequent), syncope, vertigo, lightheadedness, edema, palpitation, arrhythmia, postural hypotension, tachycardia, peripheral ischemia. CNS: Fatigue, headache, pa-resthesia, kinetic disorders, ataxia, somnolence, nervousness, depression, insomnia. Musculoskeletal: Ar-thralgia, arthritis, muscle weakness, muscle cramps, myalgia, hypertonia. GU: Polyuria, sexual dysfunction, urinary incontinence, urinary frequency. GI: Nausea, diarrhea, constipation, dyspepsia, flatulence, abdominal pain, vomiting. Respiratory: Fatigue or malaise, rhinitis, epistaxis, dyspnea. Miscellaneous: Rash, pruritus, flushing, abnormal vision, conjunctivitis, eye pain, tinnitus, chest pain, asthenia, facial edema, generalized pain, slight weight gain. Drug Interactions CNS Depressants / T Hypotensive effects

Indomethacin / i Hypotensive effects

NSAIDs / i Hypotensive effects Sympathomimetics / i Hypotensive Effects

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