Cefepime hydrochloride

[SEF-eh-pim] Pregnancy Category: B Maxipime [Rx]

Classification: Cephalosporin

See also Cephalosporins. Action/Kinetics: Antibacterial activity against both gram-negative and gram-positive pathogens, including those resistant to other ß-lactam antibiotics. High affinity for the multiple penicillin-binding proteins that are essential for cell wall synthesis. Peak serum levels, after IV: 78 mcg/mL. tV2, terminal: 2 hr. About 85% of the drug is excreted unchanged in the urine. Uses: Uncomplicated and complicated UTIs (including pyelonephritis) caused by Escherichia coli or Klebsiella pneumoniae; when the infection is severe or caused by E. coli, K. pneumoniae, or Proteus mirabilis; when the infection is mild to moderate, including infections associated with concurrent bacteremia with these microorganisms. Uncomplicated skin and skin structure infections caused by Staphylococcus aureus (methicillin-susceptible strains only) or Streptococcus pyogenes. Moderate to severe pneumonia due to Streptococcus pneumoniae, including cases associated with concurrent bactere-mia, Pseudomonas aeruginosa, K. pneumoniae, or Enterobacter species. Monotherapy for empiric treatment of febrile neutropenia. Contraindications: Use in those who have had an immediate hyper-sensitivity reaction to cefepime, ce-phalosporins, pencillins, or any other ß-lactam antibiotics. Special Concerns: Use with caution during lactation. Safety and efficacy have not been determined in children less than 12 years of age. Side Effects: See Cephalosporins. The most common side effects include rash, phlebitis, pain, and/or inflammation.

Drug Interactions Aminoglycosides / T Risk of neph-rotoxicity and ototoxicity

Furosemide / T Risk of nephrotoxicity

How Supplied: Powder for injection: 500 mg, 1 g, 2 g

Dosage-

Mild to moderate uncomplicated or complicated UTIs, including pyelonephritis, due to E. coli, K. pneumoniae, or P. mirabilis. Adults and children over 12 years: 0.5-1 g IV or IM (for E. coli infections) q 12 hr for 7-10 days.

Severe uncomplicated or complicated UTIs, including pyelonephritis, due to E. coli or K. pneumoniae. Adults and children over 12 years: 2 g IV q 12 hr for 10 days.

Moderate to severe pneumonia due to S. pneumoniae, P. aeruginosa, K. pneumoniae, or Enterobacter species.

Adults and children over 12 years: 1-2 g IV q 12 hr for 10 days.

Moderate to severe uncomplicated skin and skin structure infections due to S. aureus or S. pyogenes. Adults and children over 12 years: 2 g IV q 12 hr for 10 days.

Febrile neutropenia. 2 g IV q 8 hr for 7 days, or until resolution of neutropenia.

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