Cefixime oral

[seh-FIX-eem] Pregnancy Category: B Suprax [Rx]

Classification: Cephalosporin, third-generation

See also Anti-Infectives and Cephalo-sporins.

Action/Kinetics: Stable in the presence of beta-lactamase enzymes. Peak serum levels: 2-6 hr. tv2: averages 3-4 hr. About 50% excreted unchanged in the urine and approximately 10% in the bile.

Uses: Uncomplicated UTIs caused by E. coli and P. mirabilis. Otitis media due to H. influenzae (beta-lacta-mase positive and negative strains), Moraxella catarrhalis, and S. pyogenes. Pharyngitis and tonsillitis caused by S. pyogenes. Acute bronchitis and acute exacerbations of chronic bronchitis caused by S. pneumoniae and H. influenzae (beta-lactamase positive and negative strains). Uncomplicated cervical or urethral gonorrhea due to N. gonorrhoeae (both penicillinase- and non-penicillinase-producing strains). Contraindications: See also Ce-phalosporins.

Special Concerns: Safe use in infants less than 6 months old has not been established.

Side Effects: See also Cephalosporins. Additional Side Effects: GI: Flatulence. Hepatic: Elevated alkaline phosphatase levels. Renal: Transient increases in BUN or creatinine. Drug Interactions: See also Cephalosporins.

How Supplied: Powder for reconstitution: 100 mg/5 mL; Tablet: 200 mg, 400 mg

Dosage-

• Oral Suspension, Tablets Adults: Either 400 mg once daily or 200 mg q 12 hr. Children: Either 8 mg/kg once daily or 4 mg/kg q 12 hr. Clients on renal dialysis or in whom CCR is 21-60 mL/min, the dose should be 75% of the standard dose (i.e., 300 mg/day). If the CCR is less than 20 mL/min, the dose should be 50% of the standard dose (i.e., 200 mg/day).

Uncomplicated gonorrhea. One 400-mg tablet.

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