Cefuroxime axetil

[sef-your-OX-eem] Pregnancy Category: B

Ceftin (Rx)

Classification: Cephalosporin, second-generation

See also Anti-Infectives and Cephalo-sporins.

Action/Kinetics: Cefuroxime axetil is used PO, whereas cefuroxime sodium is used either IM or IV. Uses: PO (axetil). Pharyngitis, tonsillitis, otitis media, sinusitis, acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis, uncomplicated UTIs, uncomplicated skin and skin structure infections, uncomplicated gonorrhea (urethral and endocervical) caused by non-penicillinase-producing strains of Neisseria gonorrhoeae. Early Lyme disease due to Borrelia burgdorferi. The suspension is indicated for children from 3 months to 12 years to treat pharyngitis, tonsillitis, acute bacterial otitis media, and impetigo. Contraindications: Hypersensitivity to cephalosporins. Use in infants < 1 month.

Special Concerns: Hypersensitivity to penicillin antibiotics. Those with renal disease.

Side Effects: See also Cephalosporins. Additional Side Effects: Decrease in H&H.

Drug Interactions: See also Cepha-losporins.

How Supplied: Powder for reconstitution: 125 mg/5 mL; Tablet: 125 mg, 250 mg, 500 mg.

Dosage-

Pharyngitis, tonsillits. Adults and children over 13 years: 250 mg q 12 hr for 10 days. Children: 125 mg q 12 hr for 10 days.

Acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis, uncomplicated skin and skin structure infections. Adults and children over 13 years: 250 or 500 mg q 12 hr for 10 days (5 days for secondary bacterial infections of acute bronchitis).

CELECOXIB

Uncomplicated UTIs. Adults and children over 13 years: 125 or 250 mg q 12 hr for 7-10 days. Infants and children less than 12 years: 125 mg b.i.d.

Acute otitis media. Children: 250 mg b.i.d. for 10 days.

Uncomplicated gonorrhea. Adults and children over 13 years: 1,000 mg as a single dose.

Early Lyme disease. 500 mg/day for 20 days. • Suspension

Pharyngitis, tonsillitis. Children, 3 months to 12 years: 20 mg/kg/day in 2 divided doses, not to exceed 500 mg total dose/day, for 10 days.

Acute otitis media, impetigo. Children, 3 months to 12 years: 30 mg/kg/day in 2 divided doses, not to exceed 1,000 mg total dose/day, for 10 days.

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