[klor-PROH-pah-myd] Pregnancy Category: C

Apo-Chlorpropamide M, Diabinese, Novo-Propamide M [Rx] Classification: Sulfonylurea, first-generation

See also Antidiabetic Agents: Hypoglycemic Agents and Insulin. Action/Kinetics: May be effective in clients who do not respond well to other antidiabetic agents. Onset: 1 hr. tv2: 35 hr. Time to peak levels:

2-4 hr. Duration: Up to 60 hr (due to slow excretion). Eighty percent metabolized in liver; 80%-90% excreted in the urine.

Additional Uses: Non-FDA Approved Uses: Neurogenic diabetes insipidus.

Special Concerns: If the client is susceptible to fluid retention or has impaired cardiac function, frequent monitoring is necessary. Additional Side Effects: Side effects are frequent. Severe diarrhea, occasionally accompanied by bleeding in the lower bowel. Relieve severe GI distress by dividing total daily dose in half. In older clients, hypogly-cemia may be severe. Inappropriate ADH secretion, leading to hypona-tremia, water retention, low serum osmolality, and high urine osmolality.

Additional Drug Interactions Disulfiram / More likely to interact with chlorpropamide than other oral antidiabetics

Probenecid / T Effect of chlorpropa-mide

Sodium bicarbonate / l Effect of chlorpropamide due to T excretion by kidney

How Supplied: Tablet: 100 mg, 250 mg



Adults, middle-aged clients, mild to moderate diabetes, initial: 250

mg/day as a single or divided dose; geriatric, initial: 100-125 mg/day. All clients, maintenance: 100-250 mg/day as single or divided doses. Severe diabetics may require 500 mg/day; doses greater than 750 mg/day are not recommended.

Neurogenic diabetes insipidus. Adults: 200-500 mg/day.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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