See also Anti-Infectives and Penicillins.
Content: The Powder for Oral Suspension of Ampicillin with Probenecid contains 35 g ampicillin and 1 g probenecid per bottle. Action/Kinetics: Synthetic, broad-spectrum antibiotic suitable for gram-negative bacteria. Acid resistant, destroyed by penicillinase. Absorbed more slowly than other penicillins. From 30% to 60% of PO dose absorbed from GI tract. Peak serum levels: PO: 1.8-2.9 mcg/mL after 2 hr; IM, 4.5-7 mcg/mL. tvi: 80 min— range 50-110 min. Partially inactivated in liver; 25%-85% excreted unchanged in urine.
Uses: Infections of respiratory, GI, and GU tracts caused by Shigella, Salmonella, Escherichia coli, Hemo-philus influenzae, Proteus strains, Neisseria gonorrhoeae, N. meningitidis, and Enterococcus. Also, otitis media in children, bronchitis, rat-bite fever, and whooping cough. Penicillin G-sensitive staphylococci, streptococci, pneumococci.
Contraindications: Hypersensitivity to penicillins.
Special Concerns: Hypersensitivity to cephalosporins. Use in neonates. Side Effects: See also Anti-Infectives and Penicillins.
Drug Interactions: See also Anti-Infectives and Penicillins. Probenecid / T Ampicillin concentrations.
How Supplied: Ampicillin oral: Capsule: 250 mg, 500 mg; Powder for reconstitution: 125 mg/5 mL, 250 mg/5 mL.Ampicillin with Probenecid: See Content. Ampicillin sodium parenteral: Powder for injection: 125 mg, 250 mg, 500 mg, 1 g, 2 g, 10 g
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