Classification Antihistamine

See also Antihistamines. Action/Kinetics: Fexofenadine, a metabolite of terfenadine, is an H1-his-tamine receptor blocker. Low to no sedative or anticholinergic effects. Onset: Rapid. Peak plasma levels: 2.6 hr. t!/2, terminal: 14.4 hr. Approximately 90% of the drug is excreted through the feces (80%) and urine (10%) unchanged. Uses: Seasonal allergic rhinitis in adults and children 12 years of age and older.

Contraindications: Hypersensitiv-ity; troglitazone.

Special Concerns: Use with care during lactation. Safety and efficacy have not been determined in children less than 12 years of age. Side Effects: CNS: Drowsiness, fatigue. GI: Nausea, dyspepsia. Miscellaneous: Viral infection (flu, colds), dysmenorrhea, sinusitis, throat irritation.

Drug Interactions: No differences in side effects or the QTc interval were observed when fexofenadine was given with either erythromycin or ketoconazole.

How Supplied: Capsule: 60 mg

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