See also Antihyperlipidemic Agents—HMG-CoA Reductase Inhibitors.
Action/Kinetics: tV2: 1.2 hr. Undergoes extensive first-pass metabolism. Significantly bound (greater than 98%) to plasma protein. Metabolized in the liver with 90% excreted through the feces and 5% through the urine.
Uses: Adjunct to diet for the reduction of elevated total and LDL cholesterol levels in clients with primary hyper-cholesterolemia. The lipid-lowering effects of fluvastatin are enhanced when it is combined with a bile-acid binding resin or with niacin. To slow the progression of coronary atherosclerosis in coronary heart disease. Contraindications: Hypersensitiv-ity, active liver disease, pregnancy, lactation, children under the age of 18.
Special Concerns: Use with caution in clients with severe renal impairment.
Side Effects: Side effects listed are those most common with fluvastatin. A complete list of possible side effects is provided under Antihyperlipidem-ic Agents—HMG-CoA Reductase Inhibitors. GI: N&V, diarrhea, abdominal pain or cramps, constipation, flatulence, dyspepsia, tooth disorder. Musculoskeletal: Muscle cramps or pain, back pain, arthropathy. CNS: Headache, dizziness, insomnia. Respiratory: Upper respiratory infection, rhinitis, cough, pharyngitis, sinusitis, bronchitis. Miscellaneous: Rash, pruritus, fatigue, influenza, allergy, accidental trauma.
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