Classification Opioid antagonist

See also Opioid Antagonists. Action/Kinetics: Competitively binds to opiate receptors, thereby reversing or preventing the effects of narcotics. Peak plasma levels: 1 hr. Duration: 24-72 hr. Metabolized in the liver; a major metabolite—6-beta-naltrexol—is active. Peak serum levels, after 50 mg: naltrexone, 8.6 ng/mL; 6-beta-naltrexol, 99.3 ng/mL. tvi: naltrexone, approximately 4 hr; 6-beta-naltrexol, 13 hr. Naltrexone and its metabolites are excreted in the urine. Uses: To prevent opioid use in former narcotic addicts. Adjunct to the psychosocial treatment for alcoholism. Non-FDA Approved Uses: To treat eating disorders and postconcus-sional syndrome not responding to other approaches.

Contraindications: Clients taking opioid analgesics, those dependent on opioids, those in acute withdrawal from opioids. Liver failure, acute hepatitis.

Special Concerns: Use with caution during lactation. Safety during lactation and in children under 18 years of age has not been established.

Side Effects: CNS: Headache, anxiety, nervousness, sleep disorders, dizziness, change in energy level, depression, confusion, restlessness, disorientation, hallucinations, nightmares, bad dreams, paranoia, fatigue, drowsiness. Oral: Xerostomia. GI: N&V, diarrhea, constipation, anorexia, abdominal pain or cramps, flatulence, ulcers, increased appetite, weight gain or loss, increased thirst, hemorrhoids. CV: Phlebitis, edema, increased BP, changes in ECG, palpitations, epistaxis, tachycardia. GU: Delayed ejaculation, increased urinary frequency or urinary discomfort, increased or decreased interest in sex. Respiratory: Cough, sore throat, nasal congestion, rhinor-rhea, sneezing, excess secretions, hoarseness, SOB, heaving breathing, sinus trouble. Dermatologic: Rash, oily skin, itching, pruritus, acne, cold sores, alopecia, athlete's foot. Musculoskeletal: Joint/muscle pain, muscle twitches, tremors, pain in legs, knees, or shoulders. Ophthalmologic: Blurred vision, aching or strained eyes, burning eyes, lightsensitive eyes, swollen eyes. Other: Hepatotoxicity, tinnitus, painful or clogged ears, chills, swollen glands, inguinal pain, cold feet, "hot" spells, "pounding" head, fever, yawning, side pains.

A severe narcotic withdrawal syndrome may be precipitated if nal-trexone is administered to a dependent individual. The syndrome may begin within 5 min and may last for up to 2 days.

How Supplied: Tablet: 50 mg


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