See also Antidiabetic Agents: Hypogly-cemic Agents.
Action/Kinetics: Lowers blood glucose by stimulating release of insulin from pancreas. Action depends on functioning beta cells in pancreatic islets. Rapidly and completely absorbed from GI tract. Peak plasma levels: 1 hr. Completely metabolized in liver with most excreted in feces.
Contraindications: Lactation. Diabetic ketoacidosis, with or without coma. Type 1 diabetes. Special Concerns: Use with caution in impaired hepatic function. Safety and efficacy have not been determined in children. Side Effects: CV: Chest pain, angina, ischemia. GI: Nausea, diarrhea, constipation, vomiting, dyspepsia. Respiratory: URI, sinusitis, rhinitis, bronchitis. Musculoskeletal: Arthralgia, back pain. Miscellaneous: Hypoglyce-mia, headache, paresthesia, chest pain, urinary tract infection, tooth disorder, allergy.
Was this article helpful?