Classification Oral antidiabetic

See also Antidiabetic Agents: Hypogly-cemic Agents.

Action/Kinetics: Lowers blood glucose by stimulating release of insulin from pancreas. Action depends on functioning beta cells in pancreatic islets. Rapidly and completely absorbed from GI tract. Peak plasma levels: 1 hr. Completely metabolized in liver with most excreted in feces.

Uses: Adjunct to diet and exercise in type 2 diabetes mellitus. In combination with metformin to lower blood glucose where hyperglycemia can not be controlled by exercise, diet, or either drug alone.

Contraindications: Lactation. Diabetic ketoacidosis, with or without coma. Type 1 diabetes. Special Concerns: Use with caution in impaired hepatic function. Safety and efficacy have not been determined in children. Side Effects: CV: Chest pain, angina, ischemia. GI: Nausea, diarrhea, constipation, vomiting, dyspepsia. Respiratory: URI, sinusitis, rhinitis, bronchitis. Musculoskeletal: Arthralgia, back pain. Miscellaneous: Hypoglyce-mia, headache, paresthesia, chest pain, urinary tract infection, tooth disorder, allergy.

Drug Interactions: See Antidiabetic Agents, Hypoglycemic Agents. How Supplied: Tablets: 0.5 mg, 1 mg, 2 mg

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