Clomipramine hydrochloride

[kloh-MIP-rah-meen] Pregnancy Category: C

Anafranil, Apo-Clomipramine M, Gen-Clomipramine M, Novo-Clopamine M (Rx)

Classification: Antidepressant, tricyclic

See also Antidepressants, Tricyclic. Action/Kinetics: Significant anti-cholinergic and sedative effects as well as moderate orthostatic hypotension. Significant serotonin uptake blocking activity and moderate blocking activity for norepinephrine. tv2: 19-37 hr. Effective plasma levels: 80-100 ng/mL. Time to reach steady state: 7-14 days. Metabolized to the active desmethylclomip-ramine.

Uses: Obsessive-compulsive disorder in which the obsessions or compulsions cause marked distress, significantly interfere with social or occupational activities, or are time-consuming. Panic attacks and cataplexy associated with narcolepsy. Contraindications: To relieve symptoms of depression. Special Concerns: Safety has not been established for use during lactation or in children less than 10 years of age.

Additional Side Effects: Hyperther-mia, especially when used with other drugs. Increased risk of seizures. Aggressive reactions, asthenia, anemia, eructation, failure to ejaculate, laryngitis, vestibular disorders, muscle weakness.

How Supplied: Capsule: 25 mg, 50 mg, 75 mg


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