See individual drugs. Effective over a wide dosage range. Dosage is usually increased gradually to minimize side effects over 7 days until the minimal effective dose is attained. Dosage is increased more gradually in elderly or debilitated clients because they are more susceptible to the effects and side effects of drugs. After symptoms are controlled, dosage is gradually reduced to maintenance levels. It is usually desirable to keep chronically ill clients on maintenance levels indefinitely. Medication, especially in clients on high dosages, should not be discontinued abruptly.

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