Drug Interactions

Alcohol, ethyl / Potentiation or addition of CNS depressant effects. Concomitant use may lead to drowsiness, lethargy, stupor, respiratory collapse, coma, or death Aluminum salts (antacids) / i Absorption from GI tract

Amphetamine / l Effect of amphetamine by l uptake of drug to the site of action

Anesthetics, general / See Alcohol Antacids, oral / l Effect of pheno-thiazines due to l absorption from GI tract

Antianxiety drugs / See Alcohol Anticholinergic drugs / Additive anticholinergic side effects and/or l antipsychotic effect Antidepressants, tricyclic / Additive anticholinergic side effects Barbiturate anesthetics / T Chance of tremor, involuntary muscle activity, and hypotension Barbiturates / See Alcohol; also, barbiturates may l effect due to T breakdown by liver CNS depressants / See Alcohol; also, l effect of phenothiazines due to T breakdown by liver Hydantoins / T Risk of hydantoin toxicity

MAO inhibitors / T Effect of pheno-thiazines due to l breakdown by liver

Meperidine / T Risk of hypotension and sedation

Opioid Analgesics / See Alcohol Phenytoin / T Effect of phenytoin due to l breakdown by liver Sedative-hypnotics, nonbarbiturate / See Alcohol

Succinylcholine / T Muscle relaxation

Tricyclic antidepressants / T Serum levels of tricyclic antidepressant

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