Drug Interactions

Anesthetics, general / Additive depression of myocardium Anticholinergic agents / Counteract bradycardia produced by beta-adrenergic blockers Epinephrine / Beta blockers prevent beta-adrenergic action of epineph-rine but not alpha-adrenergic action ^ T systolic and diastolic BP and l HR

Fentanyl and derivatives / l Increased hypotension and cardiac depression

Indomethacin / l Effect of beta blockers possibly due to inhibition of prostaglandin synthesis Lidocaine / T Effect of lidocaine due to l breakdown by liver NSAIDs / l Effect of beta blockers, possibly due to inhibition of prosta-glandin synthesis

Salicylates / l Effect of beta blockers, possibly due to inhibition of prostaglandin synthesis Sympathomimetics / Reverse effects of beta blockers

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