Drug Interactions

Acetaminophen / T Risk of hepato-toxicity due to T rate of formation of hepatotoxic acetaminophen metabolite

Alcohol / T Risk of GI ulceration or hemorrhage

Anabolic steroids / T Risk of edema Antacids / l Effect of corticoster-oids due to l absorption from GI tract

Antibiotics, broad-spectrum / Concomitant use may result in emergence of resistant strains, leading to severe infection

Anticholinergics / Combination T intraocular pressure; will aggravate glaucoma

Barbiturates / l Effect of corticos-teroids due to T breakdown by liver Ephedrine / l Effect of corticoster-oids due to T breakdown by liver Immunosuppressant drugs / T Risk of infection

Indomethacin / T Chance of GI ulceration

Ketoconazole / l Effect of corticos-teroids due to T rate of clearance Muscle relaxants, nondepolarizing / l Effect of muscle relaxants Neuromuscular blocking agents / T Risk of prolonged respiratory depression or paralysis NSAIDs / T Risk of GI hemorrhage or ulceration

Phenobarbital / l Effect of corticos-teroids due to T breakdown by liver Phenytoin / l Effect of corticoster-oids due to T breakdown by liver Rifampin / l Effect of corticoster-oids due to T breakdown by liver Salicylates / Both are ulcerogenic; also, corticosteroids may l blood salicylate levels

Streptozocin / T Risk of hyperglyce-mia

Tricyclic antidepressants / T Risk of mental disturbances

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