Drug Interactions

Alcohol / T Depressant effects CNS depressants / T Depressant effect

Levodopa / l Effect of levodopa Local anesthetics / Epidural cloni-dine ^ prolonged duration of epi-dural local anesthetics

Opioid analgesics / Potentiation of hypotensive effect of clonidine NSAIDs, especially indomethacin / l Hypotensive effects Sympathomimetics / l Hypotensive effects

Tricyclic antidepressants / Blocks antihypertensive effect How Supplied: Film, extended release: 0.1 mg/24 hr, 0.2 mg/24 hr, 0.3 mg/24 hr; Tablet: 0.1 mg, 0.2 mg, 0.3 mg

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