Drug Interactions

Anesthetics / T Risk of depression of cardiac contractility, conductivity, and automaticity as well as vascular dilation

Barbiturates / i Effect of ditiazem Carbamazepine / T Effect of diltia-zem due to i breakdown by liver

Cimetidine / T Bioavailability of dil-tiazem

Cyclosporine / T Effect of cyclospo-rine possibly leading to renal toxic-ity

Digoxin / T Serum digoxin levels are possible M Indomethacin / i Effect of diltiazem Lithium / T Risk of neurotoxicity NSAIDs / i Possible effect of diltia-zem

Phenobarbital / i Effect of diltia-zem

Ranitidine / T Bioavailability of dil-tiazem

Theophyllines / T Risk of pharmaco-logic and toxicologic effects of theophyllines

Other drugs with hypotensive effects / T Effect of diltiazem How Supplied: Capsule, Extended Release: 60 mg, 90 mg, 120 mg, 180 mg, 240 mg, 300 mg, 360 mg; Injection: 5 mg/mL; Powder for injection: 25 mg Tablet: 30 mg, 60 mg, 90 mg, 120 mg

Dosage-

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