Drug Interactions

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Alcohol / Possible Antabuse-like syndrome, especially facial flushing and SOB. Also, l effect of oral hy-poglycemic due to T breakdown by liver

Beta-adrenergic blocking agents / l Hypoglycemic effect; also, symptoms of hypoglycemia may be masked

Fluconazole / T Hypoglycemic effect

Histamine H2 antagonists / T Hypoglycemic effect due to i breakdown by liver

Magnesium salts / T Hypoglycemic effect

MAO inhibitors / T Hypoglycemic effect due to i breakdown by liver Miconazole / T Effect of oral hypo-glycemics

Nicotinic acid / i Effect of oral hy-poglycemics

NSAIDs / T Hypoglycemic effect of oral antidiabetics

Phenobarbital / i Effect of oral hy-poglycemics due to T breakdown by liver

Phenothiazines / T Requirements for sulfonylureas due to i release of insulin

Phenylbutazone / T Effect of oral hypoglycemics due to i breakdown by liver, i plasma protein binding, and i renal excretion Probenecid / T Hypoglycemic effect Salicylates / T Effect of oral hypo-glycemics by i plasma protein binding

Sulfonamides / T Effect of oral hy-poglycemics by i plasma protein binding and i breakdown by liver Sympathomimetics / T Requirements for sulfonylureas Tricyclic antidepressants / T Hypo-glycemic effect

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