Drug Interactions

Anticholinergic agents, atropine / Additive anticholinergic effects Barbiturates / l Effects Cholinergic agents / Anticholinergic activity of procainamide antagonizes effect of cholinergic drugs Ethanol / Effect of procainamide may be altered, but because the main metabolite is active as an anti-arrhythmic, specific outcome not clear

Lidocaine / Additive cardiodepress-ant effects

Sodium bicarbonate / T Effect of procainamide due to l excretion by the kidney

Succinylcholine / Procainamide T muscle relaxation produced by suc-cinylcholine

Trimethoprim / T Effect of procai-namide due to T serum levels How Supplied: Capsule: 250 mg, 375 mg, 500 mg; Injection: 100

mg/mL, 500 mg/mL; Tablet: 250 mg, 375 mg, 500 mg; Tablet, extended release: 250 mg, 500 mg, 750 mg, 1000 mg

Dosage-

• Capsules, Extended-Release Tablets, Tablets

Adults, initial: 50 mg/kg/day in divided doses q 3 hr. Usual, 40-50 kg: 250 mg q 3 hr of standard formulation or 500 mg q 6 hr of sustained-release; 60-70 kg: 375 mg q 3 hr of standard formulation or 750 mg q 6 hr of sustained-release; 80-90 kg: 500 mg q 3 hr of standard formulation or 1 g q 6 hr of sustained-release; over 100 kg: 625 mg q 3 hr of standard formulation or 1.25 g q 6 hr of sustained-release. Pediatric: 15-50 mg/kg/day divided q 3-6 hr (up to a maximum of 4 g/day).

• Procanbid Extended-Release Tablets

Life-threatening arrhythmias. 500 or 1,000 mg b.i.d.

Ventricular arrhythmias. Adults, initial: 50 mg/kg/day divided into fractional doses of 1/8-1/4 given q 3-6 hr until PO therapy is possible. Pediatric: 20-30 mg/kg/day divided q 4-6 hr (up to a maximum of 4 g/day).

Arrhythmias associated with surgery or anesthesia. Adults: 100-500 mg.

Initial loading infusion: 20

mg/min (for up to 25-30 min). Maintenance infusion: 2-6 mg/min. Pediatric, initial loading dose: 3-5 mg/kg/dose over 5 min (maximum of 100 mg); maintenance: 20-80 mcg/kg/min continuous infusion (maximum of 2 g/day).

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