Drug Interactions

Alcohol / Potentiation or addition of CNS depressant effects. Concomitant use may lead to drowsiness, lethargy, stupor, respiratory collapse, coma, or death Anesthetics, general / See Alcohol Antacids / i Rate of absorption of benzodiazepines

Antidepressants, tricyclic / Concomitant use with benzodiazepines may cause additive sedative effect and/or atropine-like side effects Antihistamines / See Alcohol Barbiturates / See Alcohol Cimetidine / T Effect of benzodiaz-epines by i breakdown in liver CNS depressants / See Alcohol Erythromycin / T Effect of benzodi-azepines by i breakdown in liver Ketoconazole / T Effect of benzodi-azepines due to i breakdown in liver

Neuromuscular blocking agents / Benzodiazepines may T , i , or have no effect on the action of neu-romuscular blocking agents Opioids / See Alcohol Phenothiazines / See Alcohol Phenytoin / Concomitant use with benzodiazepines may cause T effect of phenytoin due to i breakdown by liver

Propoxyphene / T Effect of benzodiazepines due to i breakdown by liver

Ranitidine / May i absorption of benzodiazepines from the GI tract Sedative-hypnotics, nonbarbiturate / See Alcohol

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