Erythromycin base

[eh-rih-throw-MY-sin] Pregnancy Category: B (A/T/S, Erymax, Staticin, and T-Stat are C) Capsules/Tablets: Alti-Erythromycin M, Apo-Erythro Base M, Apo-Erythro-EC M, Diomycin M, E-Base Caplets, E-Base Tablets, E-Mycin, Erybid M, Eryc, Ery-Tab, Erythro-Base M, Erythromid M, Erythromycin Base Film-Tabs, Novo-Rythro EnCap M, PCE Disper-tab, PMS-Erythromycin M, Robimycin Robitabs. Gel, topical: A/T/S, Erygel. Ointment, topical: Akne-mycin. Ointment, ophthalmic: Ilotycine Ophthalmic, Pledgets: Erycette, T-Stat. Solution:, Del-Mycin, Eryderm 2%, Erymax, Erythra-Derm, Staticin, Theramycin Z, T-Stat [Rx]

Classification: Antibiotic, erythromy-cin

See also Erythromycins and Anti-Infective Agents.

Uses: See Erythromycins. Ophthalmic solution: Treatment of ocular infections (along with PO therapy) due to Streptococcus pneumoniae, Staphylococcus aureus, S. pyogenes, Corynebacterium species, Hae-

mophilus influenzae, and Bacte-roides infections. Also prophylaxis of ocular infections due to Neisseria gonorrhoeae and Chlamydia trachomatis. Topical solution: Acne vulgaris. Topical ointment: Prophylaxis of infection in minor skin abrasions; treatment of superficial infections of the skin. Acne vulgaris. Contraindications: Use of topical preparations in the eye or near the nose, mouth, or any mucous membrane. Ophthalmic use in dendritic keratitis, vaccinia, varicella, myobac-terial infections of the eye, fungal diseases of the eye. Use with steroid combinations following uncomplicated removal of a corneal foreign body.

Special Concerns: Use of other drugs for acne may result in a cumulative irritant effect. Additional Side Effects: When used topically: Erythema, desquamation, burning sensation, eye irritation, tenderness, dryness, pruritus, oily skin, generalized urticaria. Drug Interactions: Antagonism has been observed when topical eryth-romycin is used with clindamycin. How Supplied: Enteric coated capsule: 250 mg; Enteric coated tablet: 250 mg, 333 mg, 500 mg; Gel/Jelly: 2%; Ointment: 2%; Ophthalmic ointment: 5 mg/g; Pad: 2%; Solution: 1.5%, 2%; Swab: 2%; Tablet: 250 mg, 500 mg; Tablet, Coated particles: 333 mg, 500 mg

Dosage-

• Delayed-Release Capsules, Enteric-Coated Tablets, Delayed-Re-lease Tablets, Film-Coated Tablets, Suspension

Respiratory tract infections due to Mycoplasma pneumoniae. 500 mg q 6 hr for 5-10 days (up to 3 weeks for severe infections).

URTIs (mild to moderate) due to S. pyogenes and S. pneumoniae. 250-500 mg q.i.d. (or 20-50 mg/kg/day in divided doses) for 10 days.

URTIs due to H. influenzae.

Erythromycin ethylsuccinate, 50 mg/kg/day, plus sulfisoxazole, 150 mg/kg/day, given together for 10 days.

Lower respiratory tract infections (mild to moderate) due to S. pyo-genes and S. pneumoniae. 250-500 mg q.i.d. (or 20-50 mg/kg/day in divided doses) for 10 days.

Intestinal amebiasis due to Enta-moeba histolytica.

Adults: 250 mg q.i.d. for 10-14 days; pediatric: 30-50 mg/kg/day in divided doses for 10-14 days.

Legionnaire's disease. 500-1,000 mg q.i.d. for 3 weeks (or 1-4 g/day in divided doses).

Bordetella pertussis. 500 mg q.i.d. for 10 days (or 40-50 mg/kg/day in divided doses for 5-14 days).

Infections due to Corynebacteri-um diphtheriae. 500 mg q.i.d. for 10 days.

Erythrasma. 250 mg t.i.d. for 3 weeks.

Primary syphilis. 20 g in divided doses over 10 days.

Chlamydial infections. Infants: 50 mg/kg/day in four divided doses for 14 (conjunctivitis) to 21 (pneumonia) days; adults: 500 mg q.i.d. for 7 days or 250 mg q.i.d. for 14 days for urogenital infections.

Mild to moderate skin and skin structure infections due to S. pyo-genes and S. aureus. 250-500 mg q 6 hr (or 50 mg/kg/day in divided doses—to a maximum of 4 g/day) for 10 days.

Listeria monocytogenes infections.

500 mg q 12 hr (or 250 mg q 6 hr), up to maximum of 4 g/day.

Pelvic inflammatory disease, acute N. gonorrhoeae. Erythromycin lactobionate, 500 mg IV q 6 hr for 3 days; then, 250 mg erythromycin base q 6 hr for 7 days. Alternatively for pelvic inflammatory disease, 500 mg PO q.i.d. for 10-14 days.

Prophylaxis of initial or recurrent rheumatic fever. 250 mg b.i.d.

Bacterial endocarditis due to al-pha-hemolytic streptococcus. Adults: 1 g 2 hr prior to the procedure; then, 500 mg 6 hr after the initial dose. Pediatric, 20 mg/kg 2 hr prior to the procedure; then, 10 mg/kg 6 hr after the initial dose.

Pneumonia of infancy, conjunctivitis of the newborn, and urogenital infections during pregnancy due to C. trachomatis.

500 mg q.i.d. for 7 days (or 250 mg q.i.d. for 14 days).

Nongonococcal urethritis due to Ureaplasma urealyticum. 500 mg q.i.d. for at least 7 days.

Erythrasma due to Corynebacteri-um minutissimum. 250 mg t.i.d. for 21 days.

• Ophthalmic Ointment Mild to moderate infections.

Acute infections. 0.5 in. q 3-4 hr until improvement is noted.

Prophylaxis of neonatal gonococcal or chlamydial conjunctivitis.

0.2.0.4 in. into each conjunctival sac.

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