Fluphenazine hydrochloride

[flew-FEN-ah-zeen] Apo-Fluphenazine M, Permitil, Prolixin, Moditen HCl M, PMS-Fluphenazine M [Rx]

Classification: Antipsychotic, piper-azine-type phenothiazine

236 FLUPHENAZINE

See also Antipsychotic Agents, Phen-othiazines.

Action/Kinetics: High incidence of extrapyramidal symptoms and a low incidence of sedation, anticholinergic effects, antiemetic effects, and orthostatic hypotension. The enan-thate and decanoate esters dramatically increase the duration of action. Decanoate: Onset, 24-72 hr; peak

■ plasma levels, 24-48 hr; tv2 (approximate), 14 days; duration, up to 4 weeks. Enanthate: Onset, 24-72 hr; peak plasma levels, 48-72 hr; tV2 (approximate), 3.6 days; duration, 1-3 weeks.

Fluphenazine hydrochloride can be cautiously administered to clients with known hypersensitivity to other phenothiazines.

Fluphenazine enanthate may replace fluphenazine hydrochloride if desired response occurs with hyper-sensitivity reaction to fluphenazine. Uses: Psychotic disorders. Adjunct to tricyclic antidepressants for chronic pain states (e.g., diabetic neuropathy, and clients trying to withdraw from narcotics). How Supplied: Fluphenazine deca-noate: Injection: 25 mg/mL Fluphenazine enanthate: Injection: 25 mg/mL. Fluphenazine hydrochloride: Concentrate: 5 mg/mL; Elixir: 2.5 mg/5 mL; Injection: 2.5 mg/mL; Tablet: 1 mg, 2.5 mg, 5 mg

Dosage-

Fluphenazine hydrochloride is administered PO and IM. Fluphena-zine enanthate or decanoate is administered SC and IM.

Hydrochloride. • Elixir, Oral Solution, Tablets

Psychotic disorders.

Adults and adolescents, initial: 2.5-10 mg/day in divided doses q 6-8 hr; then, reduce gradually to maintenance dose of 1-5 mg/day (usually given as a single dose, not to exceed 20 mg/day). Geriatric, emaciated, debilitated clients, initial: 1-2.5 mg/day; then, dosage determined by response. Pediatric: 0.25-0.75 mg 1-4 times/day.

Hydrochloride.

Psychotic disorders. Adults and adolescents: 1.25-2.5 mg q 6-8 hr as needed. Maximum daily dose: 10 mg. Elderly, debilitated, or emaciated clients should start with 1-2.5 mg/day. Decanoate.

Psychotic disorders. Adults, initial: 12.5-25 mg; then, the dose may be repeated or increased q 1-3 weeks. The usual maintenance dose is 50 mg/1-4 weeks. Maximum adult dose: 100 mg/dose. Pediatric, 12 years and older: 6.25-18.75 mg/week; the dose can be increased to 12.5-25 mg given q 1-3 weeks. Pediatric, 5—12 years: 3.125-12.5 mg with this dose being repeated q 1-3 weeks. Enanthate.

Psychotic disorders. Adults and adolescents: 25 mg; dose can be repeated or increased q 1-3 weeks. For doses greater than 50 mg, increases should be made in increments of 12.5 mg. Maximum adult dose: 100 mg.

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