Flutamide

[FLOO-tah-myd] Pregnancy Category: D

Euflex M, Eulexin [Rx] Classification: Antineoplastic, hormonal agent

See also Antineoplastic Agents. Action/Kinetics: Acts either to inhibit uptake of androgen or to inhibit nuclear binding of androgen in target tissues. Thus, the effect of androgen is decreased in androgen-sensitive tissues. Rapidly metabolized to active (alpha-hydroxylated derivative) and inactive metabolites in the liver and mainly excreted in the urine. t1/ of active metabolite: 6 hr (8 hr in geriatric clients). Ninety-four percent to 96% is bound to plasma proteins. Uses: In combination with leuprolide acetate (i.e., a LHRH agonist) to treat stage D2 metastatic prostatic carcinoma as well as locally confined stage B2-C prostate cancer. Contraindications: Use during pregnancy.

Side Effects: Side effects are listed for treatment of flutamide with LHRH agonist. GU: Loss of libido, impotence. CV: Hot flashes, hypertension. Oral: Dry mouth, stomatitis. GI: N&V, diarrhea, GI disturbances,

238 FLUTAMIDE

anorexia. CNS: Confusion, depression, drowsiness, anxiety, nervousness. Hematologic: Anemia, leuko-penia, thrombocytopenia, hemolytic anemia, macrocytic anemia, me-themoglobinemia. Hepatic: Hepatitis, cholestatic jaundice, hepatic en-cephalopathy, hepatic necrosis. Der-matologic: Rash, injection site irritation, erythema, ulceration, bullous

■ eruptions, epidermal necrolysis. Miscellaneous: Gynecomastia, edema, neuromuscular symptoms, pulmonary symptoms, GU symptoms, malignant breast tumors. How Supplied: Capsule: 125 mg

Dosage-

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