Gentamicin sulfate

[jen-tah-MY-sin] Pregnancy Category: C

Alcomicin M, Cidomycin M, Diogent M, Garamycin, Garamycin Cream or Ointment, Garamycin Intrathecal, Garamycin IV Piggyback, Garamycin Ophthalmic Ointment, Garamycin Ophthalmic Solution, Garamycin Pediatric, Garatec M, Genoptic Ophthalmic Liquifilm, Genoptic S.O.P. Ophthalmic, Gentacidin Ophthalmic, Gentafair, Gentak Ophthalmic, Gentamicin, Gentamicin Ophthalmic, Gentam-icin Sulfate IV Piggyback, Gentrasul Ophthalmic, G-myticin Cream or Ointment, Jenamicin, Minims Gen-tamicin M, Ocugram M, Pediatric Gentamicin Sulfate, PMS-Gentamicin Sulfate M, Schwinpharm Gentamicin M [Rx]

Classification: Antibiotic, aminogly-coside

See also Aminoglycosides. Action/Kinetics: Therapeutic serum levels: IM, 4-8 mcg/mL. Toxic serum levels: >12 mcg/mL (peak) and >2 mcg/mL (trough). Prolonged serum levels above 12 mcg/mL should be avoided. tV2: 2 hr. Can be used with carbenicillin to treat serious Pseudomonas infections; do not mix these drugs in the same flask as carbenicillin will inactivate gentamicin.

Uses: Systemic: Prevention of bacterial endocarditis in high-risk patients. Serious infections caused by Pseudomonas aeruginosa, Proteus, Klebsiella, Enterobacter, Serratia, Citrobacter, and Staphylococcus. Infections include bacterial neonatal sepsis, bacterial septicemia, and serious infections of the skin, bone, soft tissue (including burns), urinary tract, GI tract (including peritonitis), and CNS (including meningitis). Should be considered as initial therapy in suspected or confirmed gramnegative infections. In combination with carbenicillin for treating life-threatening infections due to P. aeruginosa. In combination with penicillin for treating endocarditis caused by group D streptococci. In combination with penicillin for treating suspected bacterial sepsis or staphylococcal pneumonia in the neonate. Intrathecal administration is used in combination with systemic gentamicin for treating meningitis, ventriculitis, or other serious CNS infections due to Pseudomonas. Investigational: Pelvic inflammatory disease.

Ophthalmic: Ophthalmic infections due to Staphylococcus, S. aureus, Streptococcus pneumoniae, beta-he-molytic streptococci, Corynebacterium species, Streptococcus pyogenes, Es-cherichia coli, Haemophilus influenzae, H. aegyptius, H. ducreyi, Klebsiella pneumoniae, Neisseria gonorrhoeae, Proteus species, Acine-tobacter calcoaceticus, Enterobacter aerogenes, P. aeruginosa, Serratia marcescens, Moraxella lacunata.

Topical: Prevention of infections following minor cuts, wounds, burns, and skin abrasions. Treatment of primary or secondary skin infections. Treatment of infected skin cysts and other skin abscesses when preceded by incision and drainage to permit adequate contact between the drug and the infecting bacteria, infected stasis and other skin ulcers, infected superficial burns, parony-chia, infected insect bites and stings, infected lacerations and abrasions and wounds from minor surgery. Contraindications: Ophthalmic use to treat dendritic keratitis, vaccinia, varicella, mycobacterial infections of the eye, fungal diseases of the eye, use with steroids after uncomplicated removal of a corneal foreign body.

Special Concerns: Use with caution in premature infants and neonates. Ophthalmic ointments may retard corneal epithelial healing.

Side Effects: See also Aminoglyco-sides.

Additional Side Effects: Muscle twitching, numbness, seizures, increased BP, alopecia, purpura, pseudotumor cerebri. Photosensitivi-ty when used topically. After ophthalmic use: Transient irritation, burning, stinging, itching, inflammation, angioneurotic edema, urticaria, vesicular and maculopapular dermatitis, mydriasis, conjunctival paresthesia, conjunctival hyperemia, nonspecific conjunctivitis, conjuncti-val epithelial defects, lid itching and swelling, bacterial/fungal corneal ulcers.

Drug Interactions: See also Aminoglycosides.

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