Intermittent IV Infusion

Metastatic renal cell carcinoma in adults.

Each course of treatment consists of two 5-day treatment cycles separated by a rest period. Adults: 600,000 IU/kg (0.037 mg/kg) given q 8 hr by a 15-min IV infusion for a total of 14 doses. Following 9 days of rest, repeat schedule for another 14 doses, for a maximum of 28 doses per course. NOTE: Due to toxicity, clients may not be able to receive all 28 doses (median number of doses given is 20).

Retreatment for metastatic renal cell carcinoma.

Evaluate for a response about 4 weeks after completion of a course of therapy and again just prior to the start of the next treatment course. Give additional courses only if there is evidence of some tumor shrinkage following the last course and retreat-ment is not contraindicated (see preceding Contraindications). Separate each treatment course by at least 7 weeks from the date of hospital discharge.

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