Isosorbide dinitrate tablets

[eye-so-SOR-byd] Pregnancy Category: C Apo-ISDN M, Isordil Titradose, Sorbitrate (Rx)

Classification: Coronary vasodilator, antianginal drug

See also Antianginal Drugs—Nitrates/Nitrites.

Action/Kinetics: Sublingual, chewable. Onset: 2-5 min; duration: 1-3 hr. Oral Capsules/Tablets. Onset: 20-40 min; duration: 4-6 hr. Extended-release. Onset: up to 4 hr; duration: 6-8 hr.

Additional Uses: Diffuse esophageal spasm. Oral tablets are only for prophylaxis while sublingual and chewable forms may be used to terminate acute attacks of angina. Special Concerns: Use with caution during lactation. Safety and efficacy have not been established in children.

Additional Side Effects: Vascular headaches occur especially frequently.

Additional Drug Interactions

Acetylcholine / Isosorbide antagonizes the effect of acetylcholine Norepinephrine / Isosorbide antagonizes the effect of norepinephrine How Supplied: Chew tablet: 5 mg, 10 mg; Capsule, extended release: 40 mg; Tablet, extended release: 40 mg; Sublingual tablet: 2.5 mg, 5 mg, 10 mg; Tablet: 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, 40 mg


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