Loperamide hydrochloride

[loh-PER-ah-myd] Pregnancy Category: B

Alti-Loperamide M, Apo-Loperamide M, Imodium, Imodium A-D Caplets, Kaopectate II Caplets, Maalox Anti-Diarrheal Caplets, Novo-Loperamide M, Pepto Diarrhea Control, PMS-Loperamide Hydrochloride M (Imodi-um is Rx, all others are OTC) Classification: Antidiarrheal agent, systemic

Action/Kinetics: Slows intestinal motility by acting on opiate receptors on nerve endings and/or intramu-

ral ganglia embedded in the intestinal wall. Time to peak effect, capsules: 5 hr; PO solution: 2.5 hr. tv2:

9.1-14.4 hr. Twenty-five percent excreted unchanged in the feces. Uses: Rx: Symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Decrease the volume of discharge from ileosto-mies.

OTC: Control symptoms of diarrhea, including traveler's diarrhea. Non-FDA Approved Uses: With trimethoprim-sulfamethoxazole to treat traveler's diarrhea. Contraindications: Discontinue drug promptly if abdominal distention develops in clients with acute ulcer-ative colitis. In clients in whom constipation should be avoided. OTC if body temperature is over 101°F (38°C) and in presence of bloody diarrhea. Use in acute diarrhea associated with organisms that penetrate the intestinal mucosa, such as E. coli, Salmonella, and Shigella. Special Concerns: Safe use in children under 2 years of age and during lactation has not been established. Fluid and electrolyte depletion may occur in clients with diarrhea. Children less than 3 years of age are more sensitive to the narcotic effects of loperamide.

Side Effects: Oral: Dry mouth. GI: Abdominal pain, distention, or discomfort. Constipation, N&V, epigastric distress. Toxic megacolon in clients with acute colitis. CNS: Drowsiness, dizziness, fatigue. Other: Allergic skin rashes.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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