[MIG-lih-tohl] Pregnancy Category: B Glyset (Rx)

Classification: Antidiabetic, oral

See also Antidiabetic Agents. Action/Kinetics: Acts by delaying digestion of ingested carbohydrates resulting in smaller rise in blood glucose levels after meals. Does not enhance insulin secretion or increase insulin sensitivity. Does not cause hypoglycemia when given in fasted state. Absorption is saturable at high doses (i.e., only 50% to 70% of 100 mg dose is absorbed while 25 mg dose is

100% absorbed). Peak levels: 2-3 hr. Drug is not metabolized and is eliminated unchanged in urine. Dose must be reduced in those with impaired renal function. Uses: Alone as adjunct to diet to treat non-insulin-dependent diabetes. With sulfonylurea when diet plus either miglitol or a sulfonylurea alone do not result in adequate control (effects of sulfonylurea and mig-litol are additive).

Contraindications: Lactation, diabetic ketoacidosis, inflammatory bowel disease, colonic ulceration, partial intestinal obstruction, those predisposed to intestinal obstruction, chronic intestinal diseases associated with marked disorders of digestion or absorption, conditions that may deteriorate due to increased gas formation in the intestine, hypersen-sitivity to drug.

Special Concerns: When given with sulfonylurea or insulin, miglitol causes further decrease in blood sugar and increased risk of hypogly-cemia. Safety and efficacy have not been determined in children. Side Effects: GI: Flatulence, diarrhea, abdominal pain, soft stools, abdominal discomfort. Dermatolog-ic: Skin rash (transient). Drug Interactions: No drug interactions reported that would impact on dental health or the dental process. How Supplied: Tablets: 25 mg, 50 mg, 100 mg


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